Predicting protein crystallization propensity from protein sequence
نویسندگان
چکیده
منابع مشابه
Sequence-based prediction of protein crystallization, purification and production propensity
MOTIVATION X-ray crystallography-based protein structure determination, which accounts for majority of solved structures, is characterized by relatively low success rates. One solution is to build tools which support selection of targets that are more likely to crystallize. Several in silico methods that predict propensity of diffraction-quality crystallization from protein chains were develope...
متن کاملCRYSpred: accurate sequence-based protein crystallization propensity prediction using sequence-derived structural characteristics.
Relatively low success rates of X-ray crystallography, which is the most popular method for solving proteins structures, motivate development of novel methods that support selection of tractable protein targets. This aspect is particularly important in the context of the current structural genomics efforts that allow for a certain degree of flexibility in the target selection. We propose CRYSpr...
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Information about the interface sites of Protein-Protein Interactions (PPIs) is useful for many biological research works. However, despite the advancement of experimental techniques, the identification of PPI sites still remains as a challenging task. Using a statistical learning technique, we proposed a computational tool for predicting PPI interaction sites. As an alternative to similar appr...
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ژورنال
عنوان ژورنال: Journal of Structural and Functional Genomics
سال: 2010
ISSN: 1345-711X,1570-0267
DOI: 10.1007/s10969-010-9080-0